There is an association (odds ratio: 4.98, 95% confidence interval 1.43–17.28; P < 0.05) between the human leukocyte antigen HLA-B*1502 allele and lamotrigine-induced Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in Han Chinese subjects. The HLA-B*1502 allele was present in 33.3% of lamotrigine-induced SJS/TEN patients and in only 9.4% of lamotrigine tolerant patients (Zeng et al. 2015).