The poor metabolizer genotype (*4/*5) was lower (0.2%) in Amerindians than in Mexican Mestizos (5%)
Ultrarapid metabolizer genotype was higher (12.6%) in indigenous groups than in Mexican Mestizos (7%)
The most frequent alleles were:
CYP2D6*2 (0.05–0.28),
CYP2D6*4 (0.003–0.21)
multiplications (0.043–0.107).
CYP2D6*5, *6, *10 and *41 were not observed in the majority of Amerindians,
CYP2D6*3, *17, *35 and *29 were not detected.
(N=508 Amerindians;
129 Tepehuanos, 107 Huicholes and 39 Mexicaneros from the state of Durango;
74 Tarahumaras from the state of Chihuahua;
81 Coras from the state of Nayarit;
19 Seris, 15 Guarijíos and 44 Mayos from the state of Sonora.)