Fluoxetine leads to better response in major depressive disorder among Han-Chinese patients with the 5-HTTLPR l/l genotype compared with s allele carriers, as evaluated on the basis of total (P = 0.013), core (P = 0.011), and psychic-anxiety (P = 0.005) and somatic-anxiety (P = 0.002) Hamilton Depression Rating Scale-score percentage change.
(N= 121 patients with major depressive disorder; Han-Chinese sample population of Taiwan).
(Yu et al., 2002)
Female hispanic patients with major depressive disorder reported fewer side effects when treated with fluoxetine (or paroxetine) compared to non-Hispanic female patients.
Hispanic patients had 2.2 +/- 2.0 side effect complaints versus 5.1 +/- 2.5 for non-Hispanic patients (p<0.005). No differences were reported in response (HAM-D scores), side effects, or attrition rates between fluoxetine- and paroxetine-treated subjects.
N = 26: 13 Hispanic and 13 non-Hispanic patients in San Diego, Cal., prospective open-label study of paroxetine (N=18) and fluoxetine (N=8); Alonso et al., 1997.
