Dutch (Caucasians)

CYP2C19 and CYP2D6 phenotyping results in a Dutch population (Tamminga et al., 1999)

The population investigated mainly comprised Caucasian (98.9%) male (68%) volunteers mainly from the northern part of The
Netherlands. Of the total population 0.5% was Negroid and 0.6% was of Oriental origin, excluded in the results below.

Dutch pharmacokinetics (Caucasians)

Toxicity

Liberation

Administration/absorption

Distribution

Metabolism

CYP1A2

CYP2B6

CYP2C8

CYP2C9

CYP2C19

98.2 % extensive metabolizers

1.8 % poor metabolizers

(N=4301, Dutch healthy volunteers,  98.9% Caucasian, 68% males)(Tamminga et al., 1999). [Note editor: Study-population is allocated to two categories: extensive or poor metabolizers; superextensive and slow metabolizers are not mentioned. Apparently extensive and superextensive are lumped together into ‘extensive metabolizers’ and slow and poor metabolizers into ‘poor metabolizers’]  

CYP2D6

92.0 % extensive metabolizers

8.0 % poor metabolizers

(N=4301, Dutch healthy volunteers,  98.9% Caucasian, 68% males)(Tamminga et al., 1999). [Note editor: Study-population is allocated into two categories: extensive or poor metabolizers; superextensive and slow metabolizers are not mentioned. Apparently extensive and superextensive are lumped together into ‘extensive metabolizers’ and slow and poor metabolizers into ‘poor metabolizers’] 

CYP3A

Excretion

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